I-Alkyl Polyglycosides kwiiMveliso zoNakekelo loMntu

Kule minyaka ilishumi idlulileyo, uphuhliso lwezixhobo ezikrwada zeemveliso zokhathalelo lomntu luqhubele phambili kwiindawo ezintathu eziphambili:

(1) ubulali kunye nokukhathalela ulusu

(2) imigangatho yomgangatho ophezulu ngokunciphisa imveliso kunye nokulandelela ukungcola

(3) ukuhambelana kwendalo.

Imimiselo esemthethweni kunye neemfuno zabathengi ziya zivuselela uphuhliso olulandela imigaqo yenkqubo kunye nokuzinza kwemveliso. Enye inkalo yalo mgaqo kukuveliswa kwe-alkyl glycosides kwioli yemifuno kunye ne-carbohydrates evela kumthombo ohlaziyiweyo. Uphuhliso lobugcisa borhwebo lufuna inqanaba eliphezulu lolawulo kwimathiriyeli ekrwada, ukuphendula kunye neemeko zokusetyenzwa ukuze kuhlangatyezwane neemfuno zomgangatho wezinto zanamhlanje zokuthambisa kunye nokuvelisa ngexabiso elifanelekileyo. Kwintsimi yezithambiso, i-alkyl glucoside luhlobo olutsha lwe-surfactant kunye neempawu eziqhelekileyo ze-non-ionic kunye ne-anionic. Ukuza kuthi ga ngoku, inxalenye enkulu yeemveliso zorhwebo zihlambululi ezimelelwe yi-C8-14 alkyl glycosides, ezibonakaliswe ngeempawu zokunakekelwa kwesikhumba kunye neenwele. I-C12-14 i-alkyl polyglycoside isebenza njenge-emulsifier kwi-formulation ethile kwaye ngokukodwa kwi-microemulsions kunye nokufunda ukusebenza kwe-C16-18 alkyl polyglycoside njenge-self-emulsifying o / w base exutywe notywala obunamafutha.

Kwimixube yokucoca umzimba, i-surfactant entsha yanamhlanje kufuneka ihambelane kakuhle nolusu kunye nenwebu. Uvavanyo lwe-dermatological kunye ne-toxicological luyimfuneko ukuvavanya umngcipheko we-surfactant entsha kunye noyilo olubaluleke kakhulu ukuchonga ukuvuselela okunokwenzeka kweeseli eziphilayo kwi-epidermal basal layer. Kwixesha elidlulileyo, oku kube sisiseko samabango obulali obunzima. Ngelo xesha, intsingiselo yobumnene ishintshile kakhulu.Namhlanje, ubulali buqondwa njengokuhambelana ngokupheleleyo kwama-surfactants kunye ne-physiology kunye nomsebenzi wolusu lomntu.

Ngeendlela ezahlukeneyo zedermatological kunye ne-biophysical, iziphumo ze-physiological of surfactants eluswini zafundwa, ziqala ukusuka kumphezulu wolusu kwaye ziqhubela phambili ukuya kumaleko anzulu weeseli ze-basal ngokusebenzisa i-stratum corneum kunye nomsebenzi wayo wokuthintela. Ngexesha elifanayo, iimvakalelo ezizimeleyo. , njengokuvakala kwesikhumba, zirekhodwa ngolwimi lokuchukumisa namava.

I-Alkyl polyglycosides ene-C8 ukuya kwi-C16 i-alkyl chain zeqela lee-surfactants ezithambileyo zokucoca umzimba. Kuphononongo olucacileyo, ukuhambelana kwe-alkyl polyglycosides kwachazwa njengomsebenzi we-alkyl chain ecocekileyo kunye neqondo le-polymerization.Kuvavanyo olulungisiweyo lwe-Duhring Chamber Test, i-C12 i-alkyl polyglycoside ibonisa ubuninzi obuhlobene phakathi koluhlu lwe-ects yokucaphuka kancinci ngelixa i-C8, I-C10 kunye ne-C14, i-C16 i-alkyl polyglycoside ivelisa amanqaku aphantsi okucaphukisa. Oku kuhambelana noqwalaselo kunye nezinye iindidi ze-surfactants. Ukongezelela, ukucaphuka kunciphisa kancinci ngokunyuka kweqondo lepolymerization (ukusuka kwi-DP = 1.2 ukuya kwi-DP = 1.65).

Iimveliso ze-APG ezinobude betsheyini yealkyl exubeneyo zinobona kufaneleka ngokupheleleyo kunye nomlinganiselo ophezulu wealkyl glycosides ende (C12-14). Ziye zathelekiswa nokongezwa kwe-alkyl ether sulphates ethambileyo kakhulu, i-amphoteric glycine okanye i-amphoteric acetate, kunye neprotein ethambileyo kakhulu. -i-fatty acids kwi-collagen okanye ingqolowa yezinto zeproteolytic.

Iziphumo zedermatological kuvavanyo lokuhlamba ingalo lubonisa umgangatho ofanayo kunye noVavanyo lwe-Duhring Chamber elungisiweyo apho iinkqubo ezixubileyo ze-alkyl ether sulfate kunye ne-alkyl polyglycosides okanye i-amphoteric co-surfactants ziphandwa. Nangona kunjalo, uvavanyo lokuhlambela ingalo luvumela ukuhlukana okungcono kwemiphumo. Ukuqulunqwa kwe-erythema kunye ne-squamation kungancitshiswa nge-20-30 D / o ukuba malunga ne-25 °10 ye-SLES ithathelwe indawo yi-alkyl polyglycoside ebonisa ukunciphisa malunga ne-60%. Kulwakhiwo olucwangcisiweyo loqulunqo, okona kulungileyo kunokufezekiswa ngokudityaniswa kwezinto eziphuma kwiprotheni okanye ii-amphoteric.